GLP-TZ (10 Vials)
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GLP-TZ (10 Vials)

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£75.00
1 Box
(10 vials)
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£69.00
2 Boxes
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£64.00
3 Boxes
(30 vials)
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£59.00
5 Boxes
(50 vials)
For Laboratory Research Only: This listing is intended strictly for qualified researchers conducting laboratory work. Completing a purchase confirms you meet this criteria and will not use the product for personal or human consumption.
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Description

Tirzepatide

GLP-TZ is a synthetic 39-amino acid peptide, notable as the first dual GIP/GLP-1 receptor agonist, sometimes called a “twincretin,” built to activate two separate hormone pathways governing blood sugar regulation and energy metabolism at once (Dahl et al., 2021).

Mechanism of Action

  • GLP-TZ engages both the GIP receptor and the GLP-1 receptor, two pathways central to insulin release, appetite regulation, and fat metabolism
  • Research shows stronger binding affinity at the GIP receptor relative to the GLP-1 receptor, along with a signalling profile at the GLP-1 receptor that differs from selective GLP-1 agonists, a pattern described as “imbalanced and biased” agonism (Willard et al., 2020)
  • These combined pathways drive food-triggered insulin release, dampen appetite signalling in the brain, and slow gastric emptying (Nauck & D’Alessio, 2022)

Key Research Findings

  • Across the phase 3 SURPASS trial programme, tirzepatide produced greater reductions in blood glucose and body weight than selective GLP-1 agonists, including semaglutide (Dahl et al., 2021)
  • Preclinical and early clinical data show that activating both GIP and GLP-1 receptors together produces a synergistic effect on insulin response and metabolic outcomes, beyond what either receptor pathway achieves alone (Willard et al., 2020)
  • Emerging research also suggests possible relevance to metabolic liver disease, cardiovascular risk, and kidney function, reflecting how broadly GIP and GLP-1 signalling extends across tissue types (Karam et al., 2025)

For research use only. Not intended for use in humans or animals.

References

Dahl, D., Onishi, Y., Norwood, P., Huh, R., Bray, R., Patel, H., & Rodríguez, Á. (2021). https://pubmed.ncbi.nlm.nih.gov/33325008/
Karam, G., Dib, C., Tannous, M., Farhat, Z., Khaddaj, H., & Mourad, A. (2025). https://pmc.ncbi.nlm.nih.gov/articles/PMC12507501/
Nauck, M. A., & D’Alessio, D. A. (2022). https://pubmed.ncbi.nlm.nih.gov/36050763/
Willard, F. S., Douros, J. D., Gabe, M. B. N., Showalter, A. D., Stutsman, C., Bruemmer, D., Sloop, K. W., & Rosenkilde, M. M. (2020). https://pubmed.ncbi.nlm.nih.gov/32730231/

Additional information

Size

5mg/vial
What is a peptide, exactly?

Peptides are short chains of amino acids, smaller than proteins, that function as signalling molecules within biological systems. They're involved in processes such as tissue repair, immune activity, and communication between cells.

What role do peptides play in research?

Peptides are studied for how selectively they bind to receptors and influence specific cellular pathways. That precision makes them a valuable tool in laboratory settings for investigating how biological systems function at a molecular level.

What are my payment options?

Card payment, UK bank transfer, and cryptocurrency (Bitcoin and Ethereum) are all accepted.

How do I store this product correctly?

This product ships lyophilised (freeze-dried) to remain stable throughout transit and storage. Keep it cool, dry, and shielded from direct light before use, refrigerating if holding it longer term. Once reconstituted, refrigerate immediately and handle with standard sterile technique to preserve integrity.

What are your shipping timeframes?

Delivery is UK-only. Orders placed before 2pm on a business day go out same-day; anything later, or placed on a weekend, ships the next business day. Most orders arrive within 48 hours of dispatch, with tracking sent directly to you. Orders over £200 ship free automatically.

What's your policy on returns?

As a research product, this item isn't eligible for standard returns. If it arrives damaged or you received the wrong item, reach out within 48 hours and we'll get it resolved.

How is purity confirmed for this product?

Every batch is independently tested in a laboratory before listing, confirming it meets research-grade purity standards. A Certificate of Analysis is available for this product.

Tirzepatide

GLP-TZ is a synthetic 39-amino acid peptide, notable as the first dual GIP/GLP-1 receptor agonist, sometimes called a “twincretin,” built to activate two separate hormone pathways governing blood sugar regulation and energy metabolism at once (Dahl et al., 2021).

Mechanism of Action

  • GLP-TZ engages both the GIP receptor and the GLP-1 receptor, two pathways central to insulin release, appetite regulation, and fat metabolism
  • Research shows stronger binding affinity at the GIP receptor relative to the GLP-1 receptor, along with a signalling profile at the GLP-1 receptor that differs from selective GLP-1 agonists, a pattern described as “imbalanced and biased” agonism (Willard et al., 2020)
  • These combined pathways drive food-triggered insulin release, dampen appetite signalling in the brain, and slow gastric emptying (Nauck & D’Alessio, 2022)

Key Research Findings

  • Across the phase 3 SURPASS trial programme, tirzepatide produced greater reductions in blood glucose and body weight than selective GLP-1 agonists, including semaglutide (Dahl et al., 2021)
  • Preclinical and early clinical data show that activating both GIP and GLP-1 receptors together produces a synergistic effect on insulin response and metabolic outcomes, beyond what either receptor pathway achieves alone (Willard et al., 2020)
  • Emerging research also suggests possible relevance to metabolic liver disease, cardiovascular risk, and kidney function, reflecting how broadly GIP and GLP-1 signalling extends across tissue types (Karam et al., 2025)

For research use only. Not intended for use in humans or animals.

References

Dahl, D., Onishi, Y., Norwood, P., Huh, R., Bray, R., Patel, H., & Rodríguez, Á. (2021). https://pubmed.ncbi.nlm.nih.gov/33325008/
Karam, G., Dib, C., Tannous, M., Farhat, Z., Khaddaj, H., & Mourad, A. (2025). https://pmc.ncbi.nlm.nih.gov/articles/PMC12507501/
Nauck, M. A., & D’Alessio, D. A. (2022). https://pubmed.ncbi.nlm.nih.gov/36050763/
Willard, F. S., Douros, J. D., Gabe, M. B. N., Showalter, A. D., Stutsman, C., Bruemmer, D., Sloop, K. W., & Rosenkilde, M. M. (2020). https://pubmed.ncbi.nlm.nih.gov/32730231/

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