Melanotan 2

Melanotan 2

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£35.00

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Kit (10 Vials)
Research Use Only: These products are intended for laboratory research purposes only. By purchasing, you confirm you are a qualified researcher and understand this product is not for personal use.
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Description

Melanotan 2

Melanotan 2 (MT-II) is a synthetic cyclic peptide and non-selective agonist of the melanocortin receptor family, developed as an analogue of alpha-melanocyte-stimulating hormone (α-MSH) — a naturally occurring hormone involved in pigmentation, appetite regulation, and sexual function (Rösler & Giuliano, 2014).

Mechanism of Action

  • MT-II activates multiple melanocortin receptor subtypes (MC1R through MC5R), with particular research focus on MC3R and MC4R — receptors expressed in brain regions involved in appetite control, energy balance, and arousal
  • By activating these receptors in the central nervous system, MT-II has been shown in preclinical models to suppress food intake and reduce appetite-driven behaviours without producing an aversive response (Rupprecht et al., 2022)
  • Research also documents activity at MC1R, which is associated with pigment-producing cells in skin tissue (Kim et al., 2023)

Key Research Findings

  • Early clinical studies documented that MT-II initiated penile erection in 17 of 20 male subjects with erectile dysfunction in a double-blind, placebo-controlled crossover design, with increased sexual desire reported in 68% of MT-II doses versus 19% of placebo (Wessells et al., 2000)
  • Preclinical studies in rodent models demonstrated dose-dependent enhancement of peripheral nerve regeneration and partial neuroprotection against chemotherapy-induced nerve damage (Giuliano et al., 2003)
  • MT-II has been used as a pharmacological research tool to map the role of the melanocortin system across multiple physiological processes including thermogenesis, feeding behaviour, and neuroendocrine signalling (Rupprecht et al., 2022)

For research use only. Not intended for use in humans or animals.

References

Giuliano, F., Clément, P., Droupy, S., Alexandre, L., & Bernabé, J. (2003). https://pubmed.ncbi.nlm.nih.gov/12591111/

Kim, J., Cho, Y., Nam, G., & Choi, S. (2023). https://pmc.ncbi.nlm.nih.gov/articles/PMC10418475/

Rösler, M., & Giuliano, F. (2014). https://pubmed.ncbi.nlm.nih.gov/25096243/

Rupprecht, L. E., Doyle, M. R., Kohut, S. J., & Bergman, J. (2022). https://pubmed.ncbi.nlm.nih.gov/36155088/

Wessells, H., Levine, N., Hadley, M. E., Dorr, R., & Hruby, V. (2000). https://pubmed.ncbi.nlm.nih.gov/11035391/

Additional information

Size

10mg/vial

What are peptides?

Peptides are short chains of amino acids that act as signalling molecules in the body, playing a role in a wide range of biological processes including tissue repair, immune response, and cellular communication.

How are peptides used in research?

In research settings, peptides are studied for their ability to interact with specific receptors and biological pathways. This makes them valuable tools for scientific and laboratory analysis, helping researchers better understand how the body functions at a cellular level.

What payment methods do you accept?

We currently accept Credit Card, SEPA bank transfer, iDeal, Google Pay, Apple Pay, and Cryptocurrency (Bitcoin, Ethereum, and USDT).

How should I store my peptides?

All peptides are supplied in lyophilised (freeze-dried) form, ensuring stability during shipping and long-term storage. Unreconstituted vials should be kept in a cool, dry place away from direct light, with refrigeration recommended for extended periods. Once reconstituted for research purposes, peptides should be kept refrigerated and handled using sterile laboratory practices to maintain integrity throughout use.

How does shipping and delivery work?

Orders are processed and dispatched within 48 hours of purchase. Delivery typically takes 6-9 business days depending on your location. Tracking information is available directly on our website. Free shipping is applied automatically on all orders over 150 euros.

Do you offer refunds or returns?

Due to the nature of research products, we are unable to accept returns. However if your order arrives damaged or incorrect please contact us within 48 hours.

How can I be sure of product quality?

All our products are lab-tested by Janoshik to ensure high purity and compliance with research-grade quality standards.

Melanotan 2

Melanotan 2 (MT-II) is a synthetic cyclic peptide and non-selective agonist of the melanocortin receptor family, developed as an analogue of alpha-melanocyte-stimulating hormone (α-MSH) — a naturally occurring hormone involved in pigmentation, appetite regulation, and sexual function (Rösler & Giuliano, 2014).

Mechanism of Action

  • MT-II activates multiple melanocortin receptor subtypes (MC1R through MC5R), with particular research focus on MC3R and MC4R — receptors expressed in brain regions involved in appetite control, energy balance, and arousal
  • By activating these receptors in the central nervous system, MT-II has been shown in preclinical models to suppress food intake and reduce appetite-driven behaviours without producing an aversive response (Rupprecht et al., 2022)
  • Research also documents activity at MC1R, which is associated with pigment-producing cells in skin tissue (Kim et al., 2023)

Key Research Findings

  • Early clinical studies documented that MT-II initiated penile erection in 17 of 20 male subjects with erectile dysfunction in a double-blind, placebo-controlled crossover design, with increased sexual desire reported in 68% of MT-II doses versus 19% of placebo (Wessells et al., 2000)
  • Preclinical studies in rodent models demonstrated dose-dependent enhancement of peripheral nerve regeneration and partial neuroprotection against chemotherapy-induced nerve damage (Giuliano et al., 2003)
  • MT-II has been used as a pharmacological research tool to map the role of the melanocortin system across multiple physiological processes including thermogenesis, feeding behaviour, and neuroendocrine signalling (Rupprecht et al., 2022)

For research use only. Not intended for use in humans or animals.

References

Giuliano, F., Clément, P., Droupy, S., Alexandre, L., & Bernabé, J. (2003). https://pubmed.ncbi.nlm.nih.gov/12591111/

Kim, J., Cho, Y., Nam, G., & Choi, S. (2023). https://pmc.ncbi.nlm.nih.gov/articles/PMC10418475/

Rösler, M., & Giuliano, F. (2014). https://pubmed.ncbi.nlm.nih.gov/25096243/

Rupprecht, L. E., Doyle, M. R., Kohut, S. J., & Bergman, J. (2022). https://pubmed.ncbi.nlm.nih.gov/36155088/

Wessells, H., Levine, N., Hadley, M. E., Dorr, R., & Hruby, V. (2000). https://pubmed.ncbi.nlm.nih.gov/11035391/

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