MOTS-c (10 Vials)
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MOTS-c (10 Vials)

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£92.00
1 Box
(10 vials)
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£87.00
2 Boxes
(20 vials)
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£81.00
3 Boxes
(30 vials)
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£75.00
5 Boxes
(50 vials)
For Laboratory Research Only: This listing is intended strictly for qualified researchers conducting laboratory work. Completing a purchase confirms you meet this criteria and will not use the product for personal or human consumption.
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Description

MOTS-c

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring 16-amino acid peptide encoded directly by mitochondrial DNA, placing it among a rare group of peptides that originate from the mitochondrial genome rather than the nucleus. Since its identification in 2015, it’s become a notable focus in metabolic and ageing research (Lee et al., 2015).

Mechanism of Action

  • Under conditions like stress or exercise, MOTS-c relocates from the mitochondria to the cell nucleus, where it helps regulate genes tied to energy balance and stress adaptation (Bhatt et al., 2022)
  • Its main signalling route runs through AMPK activation, a central regulator of cellular energy production and use, which affects glucose uptake, fat metabolism, and insulin sensitivity (Lee et al., 2015)
  • Circulating MOTS-c levels decline with age, measuring roughly 21% lower in older subjects compared to younger ones (Bhatt et al., 2022)

Key Research Findings

  • In mouse models, MOTS-c treatment prevented insulin resistance linked to both ageing and a high-fat diet (Lee et al., 2015)
  • Kim et al. (2016) describe it as a distinct mitochondrial signalling mechanism relevant to research on obesity, diabetes, exercise physiology, and longevity
  • Additional research suggests possible roles in reducing inflammation and supporting brain function, though these areas remain under active investigation (Zhai et al., 2023)

For research use only. Not intended for use in humans or animals.

References

Bhatt, M. P., Kim, S. J., & Cohen, P. (2022). https://pmc.ncbi.nlm.nih.gov/articles/PMC9570330/
Kim, S. J., Xiao, J., Wan, J., Cohen, P., & Yen, K. (2016). https://pubmed.ncbi.nlm.nih.gov/27216708/
Lee, C., Zeng, J., Drew, B. G., Sallam, T., Martin-Montalvo, A., Wan, J., Kim, S. J., Mehta, H., Hevener, A. L., de Cabo, R., & Cohen, P. (2015). https://pubmed.ncbi.nlm.nih.gov/25738459/
Zhai, D., Ye, Z., Jiang, Y., Xu, C., Rong, Y., Yang, X., Zhao, Y., & Chen, J. (2023). https://pubmed.ncbi.nlm.nih.gov/36670507/

Additional information

Size

10mg/vial
What is a peptide, exactly?

Peptides are short chains of amino acids, smaller than proteins, that function as signalling molecules within biological systems. They're involved in processes such as tissue repair, immune activity, and communication between cells.

What role do peptides play in research?

Peptides are studied for how selectively they bind to receptors and influence specific cellular pathways. That precision makes them a valuable tool in laboratory settings for investigating how biological systems function at a molecular level.

What are my payment options?

Card payment, UK bank transfer, and cryptocurrency (Bitcoin and Ethereum) are all accepted.

How do I store this product correctly?

This product ships lyophilised (freeze-dried) to remain stable throughout transit and storage. Keep it cool, dry, and shielded from direct light before use, refrigerating if holding it longer term. Once reconstituted, refrigerate immediately and handle with standard sterile technique to preserve integrity.

What are your shipping timeframes?

Delivery is UK-only. Orders placed before 2pm on a business day go out same-day; anything later, or placed on a weekend, ships the next business day. Most orders arrive within 48 hours of dispatch, with tracking sent directly to you. Orders over £200 ship free automatically.

What's your policy on returns?

As a research product, this item isn't eligible for standard returns. If it arrives damaged or you received the wrong item, reach out within 48 hours and we'll get it resolved.

How is purity confirmed for this product?

Every batch is independently tested in a laboratory before listing, confirming it meets research-grade purity standards. A Certificate of Analysis is available for this product.

MOTS-c

MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) is a naturally occurring 16-amino acid peptide encoded directly by mitochondrial DNA, placing it among a rare group of peptides that originate from the mitochondrial genome rather than the nucleus. Since its identification in 2015, it’s become a notable focus in metabolic and ageing research (Lee et al., 2015).

Mechanism of Action

  • Under conditions like stress or exercise, MOTS-c relocates from the mitochondria to the cell nucleus, where it helps regulate genes tied to energy balance and stress adaptation (Bhatt et al., 2022)
  • Its main signalling route runs through AMPK activation, a central regulator of cellular energy production and use, which affects glucose uptake, fat metabolism, and insulin sensitivity (Lee et al., 2015)
  • Circulating MOTS-c levels decline with age, measuring roughly 21% lower in older subjects compared to younger ones (Bhatt et al., 2022)

Key Research Findings

  • In mouse models, MOTS-c treatment prevented insulin resistance linked to both ageing and a high-fat diet (Lee et al., 2015)
  • Kim et al. (2016) describe it as a distinct mitochondrial signalling mechanism relevant to research on obesity, diabetes, exercise physiology, and longevity
  • Additional research suggests possible roles in reducing inflammation and supporting brain function, though these areas remain under active investigation (Zhai et al., 2023)

For research use only. Not intended for use in humans or animals.

References

Bhatt, M. P., Kim, S. J., & Cohen, P. (2022). https://pmc.ncbi.nlm.nih.gov/articles/PMC9570330/
Kim, S. J., Xiao, J., Wan, J., Cohen, P., & Yen, K. (2016). https://pubmed.ncbi.nlm.nih.gov/27216708/
Lee, C., Zeng, J., Drew, B. G., Sallam, T., Martin-Montalvo, A., Wan, J., Kim, S. J., Mehta, H., Hevener, A. L., de Cabo, R., & Cohen, P. (2015). https://pubmed.ncbi.nlm.nih.gov/25738459/
Zhai, D., Ye, Z., Jiang, Y., Xu, C., Rong, Y., Yang, X., Zhao, Y., & Chen, J. (2023). https://pubmed.ncbi.nlm.nih.gov/36670507/

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