TB-500

TB-500

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£58.00

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Kit (10 Vials)
Research Use Only: These products are intended for laboratory research purposes only. By purchasing, you confirm you are a qualified researcher and understand this product is not for personal use.
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Description

TB-500 (Thymosin Beta-4 Fragment)

TB-500 is a synthetic research peptide corresponding to the active actin-binding region (LKKTETQ) of Thymosin Beta-4 (Tβ4) — a naturally occurring protein found in almost all mammalian cells that plays a key role in tissue repair and cellular movement.

Mechanism of Action

  • TB-500’s core activity centres on binding to actin, a structural protein essential for cell shape, movement, and division. By interacting with actin, the peptide helps regulate how cells migrate to sites of injury
  • Research shows it promotes the formation of new blood vessels, supports collagen deposition, and helps reduce inflammation in preclinical wound repair models (Goldstein et al., 2012)
  • Preclinical studies demonstrate it also reduces the formation of scar tissue by decreasing the number of myofibroblasts present at wound sites (Goldstein et al., 2012)

Key Research Findings

  • Topical and systemic application of the parent Tβ4 sequence increased wound re-epithelialisation by up to 61% over controls in rodent models, with the actin-binding fragment alone demonstrating comparable repair activity (Philp et al., 2003)
  • Rahaman et al. (2024) identified that TB-500’s wound-healing activity in fibroblast models may be partially attributable to its metabolite Ac-LKKTE, highlighting the importance of metabolite profiling in ongoing research
  • The structural identity of TB-500 (Ac-LKKTETQ) has been confirmed and characterised by Esposito et al. (2012) using high-resolution mass spectrometry

For research use only. Not intended for use in humans or animals.

References

Esposito, S., Deventer, M., Van Thuyne, W., Delbeke, F. T., & Van Eenoo, P. (2012). https://pubmed.ncbi.nlm.nih.gov/22962027/

Goldstein, A. L., Hannappel, E., Sosne, G., & Kleinman, H. K. (2012). https://pubmed.ncbi.nlm.nih.gov/22074294/

Philp, D., Badamchian, M., Scheremeta, B., Nguyen, M., Goldstein, A. L., & Kleinman, H. K. (2003). https://pubmed.ncbi.nlm.nih.gov/12581422/

Rahaman, K. A., Muresan, A. R., Min, H., Son, J., Kang, M. J., & Kwon, O. S. (2024). https://www.sciencedirect.com/science/article/pii/S1570023224000412

Additional information

Size

5mg/vial

What are peptides?

Peptides are short chains of amino acids that act as signalling molecules in the body, playing a role in a wide range of biological processes including tissue repair, immune response, and cellular communication.

How are peptides used in research?

In research settings, peptides are studied for their ability to interact with specific receptors and biological pathways. This makes them valuable tools for scientific and laboratory analysis, helping researchers better understand how the body functions at a cellular level.

What payment methods do you accept?

We currently accept Credit Card, SEPA bank transfer, iDeal, Google Pay, Apple Pay, and Cryptocurrency (Bitcoin, Ethereum, and USDT).

How should I store my peptides?

All peptides are supplied in lyophilised (freeze-dried) form, ensuring stability during shipping and long-term storage. Unreconstituted vials should be kept in a cool, dry place away from direct light, with refrigeration recommended for extended periods. Once reconstituted for research purposes, peptides should be kept refrigerated and handled using sterile laboratory practices to maintain integrity throughout use.

How does shipping and delivery work?

Orders are processed and dispatched within 48 hours of purchase. Delivery typically takes 6-9 business days depending on your location. Tracking information is available directly on our website. Free shipping is applied automatically on all orders over 150 euros.

Do you offer refunds or returns?

Due to the nature of research products, we are unable to accept returns. However if your order arrives damaged or incorrect please contact us within 48 hours.

How can I be sure of product quality?

All our products are lab-tested by Janoshik to ensure high purity and compliance with research-grade quality standards.

TB-500 (Thymosin Beta-4 Fragment)

TB-500 is a synthetic research peptide corresponding to the active actin-binding region (LKKTETQ) of Thymosin Beta-4 (Tβ4) — a naturally occurring protein found in almost all mammalian cells that plays a key role in tissue repair and cellular movement.

Mechanism of Action

  • TB-500’s core activity centres on binding to actin, a structural protein essential for cell shape, movement, and division. By interacting with actin, the peptide helps regulate how cells migrate to sites of injury
  • Research shows it promotes the formation of new blood vessels, supports collagen deposition, and helps reduce inflammation in preclinical wound repair models (Goldstein et al., 2012)
  • Preclinical studies demonstrate it also reduces the formation of scar tissue by decreasing the number of myofibroblasts present at wound sites (Goldstein et al., 2012)

Key Research Findings

  • Topical and systemic application of the parent Tβ4 sequence increased wound re-epithelialisation by up to 61% over controls in rodent models, with the actin-binding fragment alone demonstrating comparable repair activity (Philp et al., 2003)
  • Rahaman et al. (2024) identified that TB-500’s wound-healing activity in fibroblast models may be partially attributable to its metabolite Ac-LKKTE, highlighting the importance of metabolite profiling in ongoing research
  • The structural identity of TB-500 (Ac-LKKTETQ) has been confirmed and characterised by Esposito et al. (2012) using high-resolution mass spectrometry

For research use only. Not intended for use in humans or animals.

References

Esposito, S., Deventer, M., Van Thuyne, W., Delbeke, F. T., & Van Eenoo, P. (2012). https://pubmed.ncbi.nlm.nih.gov/22962027/

Goldstein, A. L., Hannappel, E., Sosne, G., & Kleinman, H. K. (2012). https://pubmed.ncbi.nlm.nih.gov/22074294/

Philp, D., Badamchian, M., Scheremeta, B., Nguyen, M., Goldstein, A. L., & Kleinman, H. K. (2003). https://pubmed.ncbi.nlm.nih.gov/12581422/

Rahaman, K. A., Muresan, A. R., Min, H., Son, J., Kang, M. J., & Kwon, O. S. (2024). https://www.sciencedirect.com/science/article/pii/S1570023224000412

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